A Defined Diet Combined with Sonicated Inoculum Provides a High Incidence, Moderate Severity Form of Experimental Autoimmune Encephalomyelitis (EAE)
A defined fiber/high-sugar diet with sonicated inoculum provides for a moderate severity, high incidence, and less variable EAE. The resulting uniformity in animal response and associated cytokine patterns, and the strong link to a defined diet, suggest that this may be a more clinically translatable protocol for the induction of EAE. This is consistent with reported effects of low-fermentable diets on immune modulation in human patients with autoimmune diseases.
Authors
- Luciano de Oliveira da Cunha
- Julian Laux
- Stefan Laufer (ORCID: https://orcid.org/0000-0001-6952-1486)
- Michael Burnet (ORCID: https://orcid.org/0000-0003-4311-5441)
- Pierre Koch (ORCID: https://orcid.org/0000-0003-4620-4650)
- Mariella Martorelli
- Santiago Cruces
- Marcus Dengler (ORCID: https://orcid.org/0000-0001-5993-9088)
- Lara Wohlbold
- Christina Pokoj
- Florian Maier (ORCID: https://orcid.org/0000-0003-4951-104X)
- Tina Fischer
- Ulrike K. Hahn
- Thilo Weinstein
- Agne Vaiceliunaite
Institutions
- Synovo (Germany) (DE)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- University of Regensburg (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- ACS Pharmacology & Translational Science
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1021/acsptsci.4c00189
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
- Universität Regensburg