Atomoxetine suppresses radioresistance in glioblastoma via circATIC/miR-520d-5p/Notch2-Hey1 axis
This study revealed that ATX suppresses radioresistance through the circATIC/miR-520d-5p/Notch2-Hey1 signaling pathway. These results showed the potential of ATX as a new drug that can overcome radioresistance, a major challenge in cancer treatment, and the signaling factors identified in this mechanism suggest the possibility of use as potential targets for the diagnosis and treatment of radioresistance.
Authors
- In Hwa Bae (ORCID: https://orcid.org/0000-0002-2826-349X)
- Jae Yeon Choi (ORCID: https://orcid.org/0000-0002-0636-998X)
- Incheol Shin (ORCID: https://orcid.org/0000-0003-3172-2594)
- Hyun Jeong Seok
- Dong Hyeon Lee
Institutions
- Korea Institute of Radiological and Medical Sciences (KR)
- Hanyang University (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12964-024-01915-0
- Citations
- 5
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.19
Funders
- National Research Foundation
- National Research Foundation of Korea
- Korea Institute of Radiological and Medical Sciences
- Ministry of Science and ICT, South Korea