Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation
Our data demonstrate that CoA fueling with PTTH in pro-inflammatory and autoreactive T cells may represent a novel therapeutic approach for the treatment of autoimmune neuroinflammation.
Authors
- Stefano Angiari (ORCID: https://orcid.org/0000-0003-4434-2224)
- Rina Demjaha (ORCID: https://orcid.org/0000-0001-9725-9809)
- Tommaso Carlucci (ORCID: https://orcid.org/0000-0003-3459-361X)
- Gabriela Constantin (ORCID: https://orcid.org/0000-0001-8978-3539)
- Elena Zenaro (ORCID: https://orcid.org/0000-0003-3928-6272)
- Anika Stracke
- Simona Budui
- Eleonora Terrabuio (ORCID: https://orcid.org/0000-0002-1999-6333)
- Enrica Pietronigro (ORCID: https://orcid.org/0000-0001-7661-2247)
- Michael Khalil (ORCID: https://orcid.org/0000-0002-5350-3328)
- Simone Bach (ORCID: https://orcid.org/0000-0002-9004-3340)
- Carlo Laudanna (ORCID: https://orcid.org/0000-0003-4050-1056)
- Natalie Bordag (ORCID: https://orcid.org/0000-0002-9505-6271)
- Gabriele Angelini
- Silvia Dusi (ORCID: https://orcid.org/0000-0002-5241-9394)
- Cansu Tafrali (ORCID: https://orcid.org/0009-0003-2910-3791)
- Barbara Rossi (ORCID: https://orcid.org/0000-0002-0410-0493)
- Julia Walter
- Elena Ellmeier
- Alyssa Schnabl
Institutions
- University of Verona (IT)
- Medical University of Graz (AT)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12974-024-03270-w
- Citations
- 3
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Multiple Sclerosis Society
- Fondazione Italiana Sclerosi Multipla
- Multiple Sclerosis Society
- Worldwide Cancer Research
- Ministero dell'Università e della Ricerca
- European Research Council