WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy
WWOX is a key factor for immune escape in HCC patients, which suggests its use as a biomarker for stratified treatment with ICIs in clinical HCC patients.
Authors
- Qiongzhu Dong (ORCID: https://orcid.org/0000-0002-2433-7199)
- Ning Ren (ORCID: https://orcid.org/0000-0001-9776-2471)
- Jialei Weng (ORCID: https://orcid.org/0000-0002-4916-0799)
- Qiang Zhou (ORCID: https://orcid.org/0009-0004-0688-1053)
- Minghao Xu (ORCID: https://orcid.org/0000-0001-5656-8090)
- Zhiqiu Hu (ORCID: https://orcid.org/0000-0002-3244-1607)
- Yi Shi (ORCID: https://orcid.org/0000-0003-3005-9655)
- Shaoqing Liu (ORCID: https://orcid.org/0000-0001-5389-4771)
- Min Xu (ORCID: https://orcid.org/0000-0001-9091-6757)
- Chenhao Zhou (ORCID: https://orcid.org/0000-0002-4800-3249)
- Mien‐Chie Hung (ORCID: https://orcid.org/0000-0003-4317-4740)
- Wenxin Xu (ORCID: https://orcid.org/0009-0008-0813-5969)
- Shiguang Yang
- Yong Yi (ORCID: https://orcid.org/0000-0003-2736-4931)
Institutions
- Sun Yat-sen University (CN)
- China Medical University (TW)
- Fudan University (CN)
- Minhang District Central Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/jitc-2024-010422
- Citations
- 8
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation