839 Cancer immunotherapy foundations: developing a comprehensive immuno-oncology course for medical students

<h3>Background</h3> The rapid advancements in cancer immunotherapy have revolutionized the landscape of oncology, offering new hope and treatment paradigms for patients with various malignancies. Despite its transformative potential, cancer immunotherapy remains a complex and evolving field, necessitating comprehensive education and training for future healthcare professionals.^1–3 There is a significant need for targeted educational programs that bridge the gap between cutting-edge research, basic science, and clinical practice. <h3>Methods</h3> Clinical and basic science faculty designed and implemented of a novel elective on cancer immunotherapy for fourth-year medical students. The elective was structured to provide an in-depth understanding of the principles and mechanisms underlying cancer immunotherapy, including immune checkpoint inhibitors, Chimeric Antigen Receptor (CAR) T-cell therapy, cancer vaccines, and immune-related adverse events. The curriculum included an Immunology primer, pre- and post-quizzes, online discussion board topics, and final presentations to ensure a robust foundation in both theoretical and practical aspects of immunotherapy. Additionally, insights from clinical and basic science faculty were incorporated, fostering an environment of collaborative learning and mentorship. <h3>Results</h3> By integrating this elective into the medical school curriculum, we aimed to equip future physicians with the knowledge and skills necessary to effectively understand the basics of immunotherapy and the immune adverse events that occur in clinical settings. Student feedback indicated a significant increase in understanding and interest in cancer immunotherapy. Early exposure to this specialized field was shown to be crucial in fostering interest and expertise in oncology, ultimately improving patient outcomes through informed and innovative care. The collaborative learning environment and mentorship opportunities were particularly appreciated, highlighting the importance of a multi-faceted approach to medical education. <h3>Conclusions</h3> In conclusion, the implementation of a cancer immunotherapy elective is a vital step towards enhancing medical education and preparing the next generation of physicians to meet the challenges of modern oncology. This elective not only broadens the clinical acumen of medical students but also inspires a commitment to lifelong learning and innovation in cancer treatment and medical education. This initiative underscores the importance of evolving medical education to keep pace with scientific advancements, ensuring that emerging therapies are seamlessly translated from education and research to patient care. <h3>Acknowledgements</h3> We thank the students who completed the course and provided feedback. <h3>References</h3> Tosto SA, Alyahya J, Espinoza V, McCarthy K, Tcherni-Buzzeo M. Online learning in the wake of the COVID-19 pandemic: mixed methods analysis of student views by demographic group. <i>Soc Sci Humanit Open</i> 2023;<b>8</b>(1):100598. doi:10.1016/j.ssaho.2023.100598. Yao L, Wang Q, Ma W. Navigating the immune maze: pioneering strategies for unshackling cancer immunotherapy resistance. <i>Cancers (Basel)</i> 2023;<b>15</b>(24):5857. Published 2023 Dec 15. doi:10.3390/cancers15245857. Postow MA, Callahan MK, Wolchok JD. Immune checkpoint blockade in cancer therapy. <i>J Clin Oncol</i> 2015;<b>33</b>(17):1974–1982. doi:10.1200/JCO.2014.59.4358. <h3>Ethics Approval</h3> This project is considered IRB exempt (IRB# E23116).