Pilot Trial of Perampanel on Peritumoral Hyperexcitability in Newly Diagnosed High-grade Glioma
Glioma peritumoral glutamate concentrations correlated with high-gamma oscillation rates. Targeting glutamatergic activity with perampanel achieved similar electrocorticographic hyperexcitability levels as in levetiracetam-treated patients.
Authors
- Sandro Santagata (ORCID: https://orcid.org/0000-0002-7528-9668)
- Keith Lloyd Ligon (ORCID: https://orcid.org/0000-0002-7733-600X)
- Patrick Yung Wen (ORCID: https://orcid.org/0000-0002-0774-7700)
- Alexandra J. Golby (ORCID: https://orcid.org/0000-0001-8461-9561)
- Dustine Reich
- Steven Tobochnik (ORCID: https://orcid.org/0000-0001-9071-8398)
- E. Antonio Chiocca (ORCID: https://orcid.org/0000-0001-5183-1670)
- Jong Woo Lee (ORCID: https://orcid.org/0000-0001-5283-7476)
- Omar Arnaout (ORCID: https://orcid.org/0000-0003-3890-8615)
- Maria Kristina Dorotan (ORCID: https://orcid.org/0000-0002-0073-4982)
- Nathalie Y.R. Agar (ORCID: https://orcid.org/0000-0003-3149-3146)
- David M. Meredith (ORCID: https://orcid.org/0000-0002-7054-8624)
- Wenya Linda Bi (ORCID: https://orcid.org/0000-0002-4635-0247)
- Emily Lapinskas (ORCID: https://orcid.org/0000-0001-9860-3544)
- Sylwia A. Stopka (ORCID: https://orcid.org/0000-0003-3761-6899)
- Michael S. Regan (ORCID: https://orcid.org/0000-0001-5252-2829)
- Michael A. Mooney (ORCID: https://orcid.org/0000-0001-5428-051X)
- Md Amin Hossain (ORCID: https://orcid.org/0000-0001-7136-503X)
- Timothy R. Smith (ORCID: https://orcid.org/0009-0003-0691-7530)
- Maria Murphy
Institutions
- Brigham and Women's Hospital (US)
- Cornell University (US)
- VA Boston Healthcare System (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1849
- Citations
- 15
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.02
Funders
- U.S. Department of Veterans Affairs
- Dana-Farber Cancer Institute
- Massachusetts Life Sciences Center
- Eisai
- National Cancer Institute
- National Institute of Biomedical Imaging and Bioengineering