METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus
Our study confirmed that upregulated METTL3 promoting IRF4 expression in an m6A-dependent manner, thus causing plasma cell infiltration-mediated kidney damage of SLE. This provides new evidence for the role of m6A in SLE kidney injury.
Authors
- Zhihua Zheng (ORCID: https://orcid.org/0000-0003-1025-5384)
- Shanshan Liu (ORCID: https://orcid.org/0000-0001-8293-1025)
- Weinian Li (ORCID: https://orcid.org/0000-0001-8452-5098)
- Chun Tang (ORCID: https://orcid.org/0000-0001-6590-1617)
- Mansi Cai (ORCID: https://orcid.org/0009-0008-5381-9542)
- Xiaoping Liu (ORCID: https://orcid.org/0000-0002-7516-382X)
- Xiao Hua Wang (ORCID: https://orcid.org/0000-0002-1774-6189)
- Ailing Luo (ORCID: https://orcid.org/0000-0002-6487-6322)
- Mingcheng Huang (ORCID: https://orcid.org/0000-0002-2807-1973)
- Shiwen Yuan (ORCID: https://orcid.org/0000-0003-1477-6064)
- Yu Liu (ORCID: https://orcid.org/0000-0003-1337-2527)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou First People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12916-024-03735-y
- Citations
- 18
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.21