Low nucleotide diversity of the Plasmodium falciparum AP2-EXP2 gene among clinical samples from Ghana
Despite the recent extensive selective sweep within chromosome 6 of West African isolates, PfAP2-EXP2 of Ghanaian origin exhibits low nucleotide diversity and very low dN/dS consistent with purifying selection acting to maintain the function of an essential gene. The conservation of AP2-EXP2 is an important factor that makes it a potential drug target.
Authors
- Jilong Shen (ORCID: https://orcid.org/0000-0002-4755-3687)
- Elvis Quansah (ORCID: https://orcid.org/0000-0002-3044-680X)
- Enock K. Amoako (ORCID: https://orcid.org/0009-0005-6035-9220)
- Lucas Naam-Kayagre Amenga-Etego (ORCID: https://orcid.org/0000-0003-4468-0506)
- Chao Zhang (ORCID: https://orcid.org/0000-0001-5342-2803)
- Faustina Halm‐Lai
- Li Yu (ORCID: https://orcid.org/0000-0003-4133-5483)
- Ji Zhao
- Qingli Luo (ORCID: https://orcid.org/0000-0001-6173-353X)
- Kenneth Kofi Eduful
Institutions
- University of Cape Coast (GH)
- University of Ghana (GH)
- Anhui Medical University (CN)
- Cape Coast Technical University (GH)
- University for Development Studies (GH)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s13071-024-06545-6
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- Anhui Medical University