Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis
Our study sheds light on the paradigm of "Exercise is Medicine", providing evidence to support the use of statins combined with exercise in reducing LDL-C levels, and unveils potential avenues for clinical applications of sEH inhibitors, presenting novel prospects for therapeutic interventions in ASCVD.
Authors
- Kaijun Sun
- Leiling Liu
- Yajun Gui
- Danyan Xu (ORCID: https://orcid.org/0000-0003-2113-0800)
- Jiahui Hu (ORCID: https://orcid.org/0000-0002-6856-9899)
- Jingyuan Chen (ORCID: https://orcid.org/0000-0003-4795-3856)
- Hao Lei (ORCID: https://orcid.org/0000-0003-3412-1241)
Institutions
- Weifang Medical University (CN)
- Central South University (CN)
- Nanchang University (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1016/j.jshs.2024.101007
- Citations
- 4
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Natural Science Foundation of China