Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension
Elevated SARM1 expression was observed in the optic nerves in both the COH and I/R injury models. Downregulation of SARM1 exhibited a protective effect on RGC soma and axons in the COH model, with JNK identified as a downstream regulator of SARM1 in this context.
Authors
- Rong Zhang (ORCID: https://orcid.org/0000-0001-7906-6210)
- Jihong Wu (ORCID: https://orcid.org/0000-0003-3892-5757)
- Junfeng Li (ORCID: https://orcid.org/0009-0002-8069-8826)
- Kaidi Wang (ORCID: https://orcid.org/0000-0002-5430-9105)
- Xuejin Zhang (ORCID: https://orcid.org/0000-0002-9365-6724)
- Ting Li (ORCID: https://orcid.org/0000-0003-1377-8076)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1167/iovs.65.13.7
- Citations
- 4
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China