Progressive Optic Neuropathy in Hydrocephalic <i>Ccdc13</i> Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head
We provided knowledge of optic neuropathy from a congenital mouse model for hydrocephalus. The hydrocephalus in mice could damage the ONH by increasing the translaminar pressure gradient and negative cupping, leading to impairment in axoplasmic transport and RGC pathology. Our findings highlight the importance of the interplay between IOP and ICP in the development of glaucoma.
Authors
- Shanzhen Peng
- Xinyi Zhao (ORCID: https://orcid.org/0000-0002-8924-6431)
- Dianlei Guo (ORCID: https://orcid.org/0000-0001-7182-9164)
- Tiansen Li (ORCID: https://orcid.org/0000-0002-9537-2573)
- Yingchun Su (ORCID: https://orcid.org/0000-0001-5217-9936)
- Haotian Lin (ORCID: https://orcid.org/0000-0003-4672-9721)
- Mingjuan Wu
- Jiali Ru
- Shujuan Xu (ORCID: https://orcid.org/0000-0002-8337-6198)
- Jianmin Hu (ORCID: https://orcid.org/0000-0002-9804-9747)
- Lijing Xie
- Chunqiao Liu (ORCID: https://orcid.org/0000-0002-1513-0073)
- Tao Wen (ORCID: https://orcid.org/0000-0002-6944-0739)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0002-1752-5482)
Institutions
- Fujian Medical University (CN)
- National Institutes of Health (US)
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- National Eye Institute (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1167/iovs.65.13.5
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.27