Unravelling switch/sucrose non-fermentable (SWI-SNF) complex-deficient thoracic tumours: a clinicopathological comparative on undifferentiated tumours and non-small cell lung carcinomas with BRG1 and BRM deficiency
Tumours with intermediate features between SMARCA4-dUT and SWI/SNF-dNSCLC exist and portend an equally poor prognoses. Immunostains, including keratin, claudin-4, TTF1, HepPar1, stem cell markers, along with BRG1 and BRM testing, are essential adjuncts to morphology, while molecular studies can offer supplementary evidence in challenging cases.
Authors
- Arshi Tandon
- Prabhat Singh Malik (ORCID: https://orcid.org/0000-0003-0205-8559)
- Aruna Nambirajan (ORCID: https://orcid.org/0000-0001-7589-537X)
- Warisa Khatoon
- Ridhi Sood (ORCID: https://orcid.org/0000-0002-2719-0989)
- Anant Mohan
- Deepali Jain
- Jayashimman Vasanthraman (ORCID: https://orcid.org/0000-0002-1787-5458)
Institutions
- All India Institute of Medical Sciences Raipur (IN)
- All India Institute of Medical Sciences Bhopal (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Journal of Clinical Pathology
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1136/jcp-2024-209619
- Citations
- 1
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Indian Council of Medical Research