Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis
Markers of mitochondrial biogenesis (PGC-1α), mitochondrial import proteins (cHsp70 and mtHsp70), and type I muscle fiber CSA were significantly linked to lower-limb muscle power in older adults. These results suggest that muscle power is influenced by mitochondrial signaling. We also found that the relationship between mitochondrial mediators, inflammatory markers, and muscle power varied according to the assessment tool used.
Authors
- Robert T. Mankowski (ORCID: https://orcid.org/0000-0002-8617-9931)
- Christiaan Leeuwenburgh (ORCID: https://orcid.org/0000-0003-0826-4257)
- Casey L. Sexton (ORCID: https://orcid.org/0000-0001-7719-717X)
- Emanuele Marzetti (ORCID: https://orcid.org/0000-0001-9567-6983)
- Hélio José Coelho‐Júnior (ORCID: https://orcid.org/0000-0001-7482-9514)
- Anna Picca (ORCID: https://orcid.org/0000-0001-7032-3487)
- Kevin C.‐W. Wu (ORCID: https://orcid.org/0000-0003-0590-1396)
- Stephen D. Anton
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Alabama at Birmingham (US)
- University of Florida (US)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1016/j.jnha.2024.100408
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Ministero della Salute
- Università Cattolica del Sacro Cuore
- National Institutes of Health