Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
This study provides a comprehensive analysis of the epigenetic landscape in HCC, encompassing both chromatin accessibility and the transcriptome. Our findings reveal that ZNF93 promotes the proliferation and motility of HCC cells through transcriptional regulation of a novel oncogene, PRPF3.
Authors
- Zijie Lin
- Shuo Han (ORCID: https://orcid.org/0000-0002-4430-7296)
- Xiangyu Liu (ORCID: https://orcid.org/0000-0001-8864-3411)
- Xiyue Deng (ORCID: https://orcid.org/0000-0002-7367-4714)
- Zhongmin Li (ORCID: https://orcid.org/0000-0002-0865-4864)
- Zilin Cui (ORCID: https://orcid.org/0000-0002-0088-0322)
- Zirong Liu (ORCID: https://orcid.org/0000-0002-1731-0035)
- Wen Tong
- Tianze Wang (ORCID: https://orcid.org/0009-0001-3769-5147)
- Jinming Li (ORCID: https://orcid.org/0000-0001-8195-3038)
- Dapeng Chen (ORCID: https://orcid.org/0000-0001-8109-8879)
- Yamin Zhang (ORCID: https://orcid.org/0000-0001-7886-2901)
- Yi Bai (ORCID: https://orcid.org/0009-0007-6238-7262)
Institutions
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Nankai Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s13148-024-01769-w
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China