Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC
Our findings clarified the adverse outcome induced by high expression of ITGA5 in ccRCC patients. In vitro experiments and bioinformatical analysis identified ITGA5 function as predominantly cell proliferation, migration, angiogenesis, and macrophage recruitment. Further, we predicted immune infiltration and medication sensitivity regulation by ITGA5 and proposed a joint use of ITGA5 inhibitors and anti-angiogenetic drugs as a potential potent therapeutic strategy.
Authors
- Yiyun Huang (ORCID: https://orcid.org/0000-0002-6757-3220)
- Shuxuan Zhu (ORCID: https://orcid.org/0009-0000-6763-8381)
- Aihetaimujiang Anwaier (ORCID: https://orcid.org/0000-0002-0859-5171)
- Kaihui Wu (ORCID: https://orcid.org/0000-0002-1108-0304)
- Pang Yao (ORCID: https://orcid.org/0000-0002-6875-7435)
- Dingwei Ye (ORCID: https://orcid.org/0000-0002-6761-5195)
- Yihan Chen (ORCID: https://orcid.org/0009-0005-8009-0652)
- Zhenda Wang
- Xi Tian (ORCID: https://orcid.org/0000-0003-1965-0647)
- Hailiang Zhang (ORCID: https://orcid.org/0000-0002-8050-2494)
- Yifei Liu
- Wenhao Xu (ORCID: https://orcid.org/0000-0002-0660-9162)
- Shiqi Ye (ORCID: https://orcid.org/0009-0007-9070-443X)
- Xiangxian Che
- Yijia Chen (ORCID: https://orcid.org/0000-0001-7033-9593)
- Yue Wang (ORCID: https://orcid.org/0000-0002-3241-6356)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Xiamen University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12935-024-03546-4
- Citations
- 5
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 1.91
Funders
- Shanghai Anti-Cancer Association
- Beijing Xisike Clinical Oncology Research Foundation
- University of Twente
- Shanghai Municipal Health Bureau