Systemic immune-inflammation mediates the association between Klotho protein and metabolic syndrome: findings from a large-scale population-based study
The serum concentration of Klotho protein was negatively associated with metabolic syndrome, with the relationship being partly mediated by systemic immune inflammation. The findings of this research revealed that the Klotho protein may be a valuable biomarker for risk stratification and a potential therapeutic target for metabolic syndrome.
Authors
- Yu Li (ORCID: https://orcid.org/0000-0002-1893-9046)
- Ying Liu (ORCID: https://orcid.org/0000-0003-1662-9228)
- Yurong Wu
- Kaiyu Zhou (ORCID: https://orcid.org/0000-0002-0347-6317)
- Yongzhou Liang
- Qin Tan
Institutions
- Shanghai Jiao Tong University (CN)
- Sichuan University (CN)
- XinHua Hospital (CN)
- West China Second University Hospital of Sichuan University (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12944-024-02339-y
- Citations
- 8
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China