Interleukin 6 blockage alters the plasma metabolome in out-of-hospital cardiac arrest
Blocking the IL-6 receptor with tocilizumab early after OHCA impacts circulating metabolites, particularly those within the glycine, serine, and threonine pathways, highlighting the connection between acute systemic inflammation and metabolism. Further, early levels of TCA metabolites are independently associated with early inflammatory response and early medium-chain acylcarnitine with later markers of neurological injury.
Authors
- Rasmus Paulin Beske (ORCID: https://orcid.org/0000-0002-5880-3733)
- Christian Hassager (ORCID: https://orcid.org/0000-0002-1199-0981)
- Jesper Kjærgaard (ORCID: https://orcid.org/0000-0001-5244-0399)
- Pär I. Johansson (ORCID: https://orcid.org/0000-0001-9778-5964)
- M Meyer (ORCID: https://orcid.org/0000-0002-6312-2457)
- Laust Emil Roelsgaard Obling (ORCID: https://orcid.org/0000-0003-2927-3670)
- Jacob Eifer Møller (ORCID: https://orcid.org/0000-0003-2873-5845)
Institutions
- University of Copenhagen (DK)
- Odense University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Resuscitation
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1016/j.resuscitation.2024.110425
- Citations
- 4
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 2.76
Funders
- Hjerteforeningen
- Gentofte Hospital
- Lundbeckfonden
- Rigshospitalet
- Region Hovedstaden
- Novo Nordisk Fonden