Emerging threat of artemisinin partial resistance markers (pfk13 mutations) in Plasmodium falciparum parasite populations in multiple geographical locations in high transmission regions of Uganda
Detection of validated molecular markers of artemisinin partial resistance in multiple geographical locations in this setting provides additional evidence of emerging threat of artemisinin partial resistance in Uganda. In view of these findings, periodic genomic surveillance is recommended to detect and monitor levels of pfk13 mutations in other regions in parallel with TES to assess potential implication on delayed parasite clearance and associated treatment failure in this setting. Future studies should consider identification of potential drivers of artemisinin partial resistance in the different malaria transmission settings in Uganda.
Authors
- Pontiano Kaleebu (ORCID: https://orcid.org/0000-0001-9706-2977)
- Peter Piot
- Maria G. Zalwango
- Simon Peter Rugera (ORCID: https://orcid.org/0000-0002-3689-8751)
- Jimmy Opigo (ORCID: https://orcid.org/0009-0003-1521-4159)
- Charles Katureebe (ORCID: https://orcid.org/0009-0001-7061-1128)
- David W. Smith (ORCID: https://orcid.org/0000-0002-3107-5182)
- Bosco Agaba (ORCID: https://orcid.org/0000-0003-4601-5171)
- Qin Cheng (ORCID: https://orcid.org/0000-0001-7776-4437)
- Jye Travis (ORCID: https://orcid.org/0000-0002-7659-1877)
- Moses Robert Kamya (ORCID: https://orcid.org/0000-0001-9106-4234)
- Joseph Ngonzi (ORCID: https://orcid.org/0000-0001-5253-9516)
- Ruth Mpirirwe (ORCID: https://orcid.org/0009-0009-7925-4807)
- Martín Antonio (ORCID: https://orcid.org/0000-0002-4810-1308)
- Dembo Bakary
- Beshir Khalid
Institutions
- Mbarara University of Science and Technology (UG)
- QIMR Berghofer Medical Research Institute (AU)
- London School of Hygiene & Tropical Medicine (GB)
- Malaria Consortium (UG)
- MRC Unit the Gambia (GM)
- Infectious Diseases Research Collaboration (UG)
- World Health Organization - Uganda (UG)
- Makerere University (UG)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Malaria Journal
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12936-024-05158-9
- Citations
- 18
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 9.77
Funders
- Bill and Melinda Gates Foundation
- Medical Research Council