CYP3A4-mediated metabolism of artemisinin to 10β-hydroxyartemisinin with comparable anti-malarial potency
The major metabolite 10β-hydroxyartemisinin contributes to the antiplasmodial efficacy of ART, which should be considered when evaluation of ART dosing regimens and/or clinical outcomes.
Authors
- Fanping Zhu (ORCID: https://orcid.org/0000-0003-3656-7386)
- Pingli Li
- Shanshan Du (ORCID: https://orcid.org/0000-0001-6889-116X)
- Jie Xing (ORCID: https://orcid.org/0000-0002-7911-9906)
- Hongchang Zhou (ORCID: https://orcid.org/0000-0002-8631-3272)
- Huixiu Mao
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Institutions
- Shandong University (CN)
- Huzhou Normal University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Malaria Journal
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12936-024-05163-y
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- National Natural Science Foundation of China