Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction
This study shows the feasibility and efficacy of a variant protein associated with human longevity in contrasting pivotal risk factors for heart failure in animal models. The diabetic study revealed that sex influences the treatment efficacy.
Authors
- Annibale Alessandro Puca (ORCID: https://orcid.org/0000-0002-0347-1460)
- Monica Cattaneo
- Khaled Abdelsattar Kassem Mohammed
- Sadie C. Slater (ORCID: https://orcid.org/0000-0003-3485-3207)
- Yan Qiu (ORCID: https://orcid.org/0000-0002-3121-1455)
- Paolo Madeddu
- Seamus Gate
- Valeria Vincenza Alvino
- Vealmurugan Sekar
Institutions
- University of Bristol (GB)
- MultiMedica (IT)
- Assiut University (EG)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12933-024-02487-6
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- British Heart Foundation
- Diabetes UK
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Medical Research Council