Predictors of the effectiveness of first-line CTLA4-Ig in patients with RA: the FIRST registry
Bio-naive RA patients with low HAQ-DI scores showed high treatment efficacy with no significant difference between CTLA4-Ig and TNFi. Among patients with high baseline HAQ-DI scores, TNFi and CTLA4-Ig were more likely to be effective in those with lower and higher baseline ACPA levels, respectively.
Authors
- Yasuyuki Todoroki (ORCID: https://orcid.org/0009-0003-4646-592X)
- Hiroki Hill Kobayashi (ORCID: https://orcid.org/0000-0002-9674-0374)
- Yusuke Miyazaki (ORCID: https://orcid.org/0000-0001-5692-3881)
- Yoshiya Tanaka (ORCID: https://orcid.org/0000-0002-0807-7139)
- Yoshino Inoue
- Yoshihisa Fujino (ORCID: https://orcid.org/0000-0002-9126-206X)
- Kentaro Hanami
- Shunsuke Fukuyo (ORCID: https://orcid.org/0000-0001-7006-8826)
- Satoshi Kubo (ORCID: https://orcid.org/0000-0001-9693-9263)
- Hiroko Miyata
- Shingo Nakayamada (ORCID: https://orcid.org/0000-0002-2209-8454)
- Ayako Yamaguchi (ORCID: https://orcid.org/0000-0002-5653-1041)
- Shintaro Hirata (ORCID: https://orcid.org/0000-0002-2474-9943)
- Hiroaki Tanaka (ORCID: https://orcid.org/0000-0001-5377-4497)
Institutions
- Target (United States) (US)
- University of Occupational and Environmental Health Japan (JP)
- Institute for Transfusion Medicine (US)
- Health First (US)
- Hiroshima University Hospital (JP)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1093/rheumatology/keae598
- Citations
- 2
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- University of Occupational and Environmental Health