Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model
hUC-MSCs appear to modify and reduce the development of osteoarthritic changes in the ovine stifle joint after meniscal destabilization, an injury which commonly leads to OA in humans. These results are encouraging for the potential benefit of culture expanded UC-MSCs as an allogeneic cell therapy in patients who may have early OA following a meniscal injury of the knee.
Authors
- Frances Henson (ORCID: https://orcid.org/0000-0002-3518-1492)
- Claire Mennan (ORCID: https://orcid.org/0000-0002-0762-3214)
- Helen S. McCarthy (ORCID: https://orcid.org/0000-0001-9534-7565)
- Karina T. Wright (ORCID: https://orcid.org/0000-0001-8842-5908)
- Jade Perry (ORCID: https://orcid.org/0000-0002-5953-1389)
- Timothy Hopkins (ORCID: https://orcid.org/0000-0002-0300-8230)
- Charlotte Hulme (ORCID: https://orcid.org/0000-0002-4961-2185)
- Sally Roberts (ORCID: https://orcid.org/0000-0003-1835-327X)
- Karin Newell
- Paul Cool (ORCID: https://orcid.org/0000-0002-4985-3085)
Institutions
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- Robert Jones and Agnes Hunt Orthopaedic Hospital (GB)
- Arthritis UK (GB)
- Keele University (GB)
Publication Details
- Journal
- Cartilage
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1177/19476035241287832
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Orthopaedic Institute Limited
- Keele University
- Versus Arthritis
- Medical Research Council
- Faculty of Medicine and Health, University of Sydney