High <b>α</b>-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only
The findings highlight that immunostaining with α-SMA in pMMR colorectal tumors, especially at the tumor periphery, has the potential to identify patients with adverse prognostic features. Digital assessment of α-SMA may offer improved objectivity, accuracy, economy of time, and risk stratification for management.
Authors
- Dewi Rusnita
- Wakkas Fadhil (ORCID: https://orcid.org/0000-0002-0529-0460)
- Declan Sculthorpe (ORCID: https://orcid.org/0000-0001-7557-8454)
- Amy Denton (ORCID: https://orcid.org/0009-0002-9279-7899)
- Abhik Mukherjee (ORCID: https://orcid.org/0000-0003-1828-4155)
- Mohammad Ilyas (ORCID: https://orcid.org/0000-0003-0075-9722)
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Queen's Medical Centre (GB)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1093/ajcp/aqae145
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Bowel Cancer UK
- Bowel Research UK
- Direktorat Jenderal Pendidikan Tinggi