[PKM1 Regulates the Expression of Autophagy and Neuroendocrine Markers in Small Cell Lung Cancer].
PKM1 was differentially expressed in SCLC cell lines, and high expression of PKM1 did not affect the proliferation, but affected the migration of SCLC cells. PKM1 might affect drug sensitivity by inhibiting autophagy and regulating the expression of NE markers. These results provide a theoretical basis for exploring the role of PKM1 in SCLC.
Authors
- Peiyan Zhao (ORCID: https://orcid.org/0000-0002-6977-339X)
- Rui Zhong (ORCID: https://orcid.org/0000-0003-4570-0927)
- Lin Tian
- Hui Li (ORCID: https://orcid.org/0000-0001-6214-8308)
- Jingjing Liu (ORCID: https://orcid.org/0000-0003-3112-0147)
- Lixia Ma
- Yulong Jin
- Chenchen Tang (ORCID: https://orcid.org/0009-0006-1380-2207)
- Ying Cheng (ORCID: https://orcid.org/0000-0002-8940-8445)
- Changliang Yang (ORCID: https://orcid.org/0009-0004-0731-9855)
Institutions
- Jilin Province Tumor Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3779/j.issn.1009-3419.2024.102.33
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
Funders
- People's Government of Jilin Province
- Health Commission of Jilin Province