Protein Biomarkers of Adverse Clinical Features and Events in Sarcomeric Hypertrophic Cardiomyopathy
Proteomic profiling of sarcomeric HCM identified biomarkers associated with adverse imaging and clinical phenotypes. These circulating proteins are part of both established pathways, including neurohormonal activation and fibrosis, and less familiar pathways, including endothelial function and inflammatory proteins less well characterized in HCM. These findings highlight the value of plasma profiling to identify biomarkers of risk and to gain further insights into the pathophysiology of HCM.
Authors
- Carolyn Yung Ho (ORCID: https://orcid.org/0000-0002-7334-7924)
- Petr Jarolı́m (ORCID: https://orcid.org/0000-0002-9612-8652)
- Usman A. Tahir (ORCID: https://orcid.org/0000-0002-3657-6082)
- Julissa Zelaya-Portillo
- Paul Kolm (ORCID: https://orcid.org/0000-0003-2653-5452)
- Milind Y. Desai (ORCID: https://orcid.org/0000-0003-0010-9797)
- Hugh Watkins (ORCID: https://orcid.org/0000-0002-5287-9016)
- Christopher M. Kramer (ORCID: https://orcid.org/0000-0003-2057-7731)
- Shuliang Deng (ORCID: https://orcid.org/0000-0002-1543-2733)
- Matthias G. Friedrich (ORCID: https://orcid.org/0000-0003-1204-5647)
- Robert E. Gerszten (ORCID: https://orcid.org/0000-0002-6767-7687)
- William S. Weintraub (ORCID: https://orcid.org/0000-0002-5384-5571)
- Michael Jerosch‐Herold (ORCID: https://orcid.org/0000-0001-9018-6731)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Gaurav Tiwari (ORCID: https://orcid.org/0009-0000-2540-6005)
- Evan Appelbaum
- Patrice Desvigne‐Nickens (ORCID: https://orcid.org/0000-0003-1073-641X)
- Jeanette Schulz‐Menger (ORCID: https://orcid.org/0000-0003-3100-1092)
- John Dimarco
- Stefan Neubauer (ORCID: https://orcid.org/0000-0001-9017-5645)
- Sarahfaye Dolman (ORCID: https://orcid.org/0000-0003-3651-9069)
- Stefan K. Piechnik (ORCID: https://orcid.org/0000-0002-0268-5221)
- Raymond Y. Kwong (ORCID: https://orcid.org/0000-0001-8212-0759)
- Dong‐Yun Kim (ORCID: https://orcid.org/0000-0001-9405-4840)
Institutions
- Brigham and Women's Hospital (US)
- Lahey Hospital and Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Cleveland Clinic (US)
- University of Virginia Health System (US)
- John Radcliffe Hospital (GB)
- Lahey Medical Center (US)
- National Heart, Lung, and Blood Institute (US)
- MedStar Heart & Vascular Institute (US)
- Helios Hospital Berlin-Buch (DE)
- McGill University (CA)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1161/circheartfailure.124.011707
- Citations
- 5
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Cytokinetics
- National Institute for Health and Care Research
- British Heart Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute