Assessing sepsis-induced immunosuppression to predict positive blood cultures

The results of this study highlight the innate immune system immunosuppression state as a critical parameter for sepsis diagnosis. Notably, the present study identified a reduction in monocyte populations and specific cytokine profiles as potential predictive markers. This study showed that the LPS challenge can be used to effectively distinguish between patients with bloodstream infection leading to sepsis and those whose blood cultures are negative, providinga rapid and reliable diagnostic tool to predict positive blood cultures. The potential applicability of these findings could enhance clinical practice in terms of the accuracy and promptness of sepsis diagnosis in the ED, improving patient outcomes through timely and appropriate treatment.

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Publication Details

Journal
Frontiers in Immunology
Published
2024-11-04
DOI
https://doi.org/10.3389/fimmu.2024.1447523
Citations
4
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.55

Funders

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article

Assessing sepsis-induced immunosuppression to predict positive blood cultures

Laura García-Tejada, Pierre Malchair, Guillem López de Egea, Xose Pérez Fernández et al.
4 citations
Frontiers in Immunology
Sepsis Diagnosis and Treatment
1.55
article

Assessing sepsis-induced immunosuppression to predict positive blood cultures

Laura García-Tejada, Pierre Malchair, Guillem López de Egea, Xose Pérez Fernández, Erika P. Plata–Menchaca, Arnau Ulsamer, Dàmaris Berbel, Macarena Dastis-Arias, A Blasco, Enrique Hernández-Jiménez, Nadia García Muñoz, Joan Sabater‐Riera, Eva Molina Ramírez, Fabrizio Sbraga
article en
4 citations

Abstract

The results of this study highlight the innate immune system immunosuppression state as a critical parameter for sepsis diagnosis. Notably, the present study identified a reduction in monocyte populations and specific cytokine profiles as potential predictive markers. This study showed that the LPS challenge can be used to effectively distinguish between patients with bloodstream infection leading to sepsis and those whose blood cultures are negative, providinga rapid and reliable diagnostic tool to predict positive blood cultures. The potential applicability of these findings could enhance clinical practice in terms of the accuracy and promptness of sepsis diagnosis in the ED, improving patient outcomes through timely and appropriate treatment.

Frontiers in ImmunologyVol. 15
Instituto de Salud Carlos III (ES), Bellvitge University Hospital (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Vall d'Hebron Institut de Recerca (ES), Light Prescriptions Innovators (Spain) (ES), Banc de Sang i Teixits (ES)
European Commission, Centro para el Desarrollo Tecnológico Industrial, Universitat de Barcelona, Agència de Gestió d'Ajuts Universitaris i de Recerca
Good health and well-being
Openalex Percentile: Top 16%
Sepsis Diagnosis and Treatment
1.55
DOIOpen Access PDFOpenAlex
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