Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders

Abstract Non-alcoholic fatty liver disease and neurodegenerative disorders represent significant health challenges worldwide, with shared pathophysiological mechanisms. Evolving data indicates a bidirectional relationship between NAFLD and neurodegenerative disorders, with common risk factors, such as metabolic syndrome, inflammation, oxidative stress, and genetic predisposition, contributing to both conditions. Mechanistic links connecting NAFLD and neurodegeneration include systemic inflammation, dysregulation of the gut-liver-brain axis, and vascular dysfunction. This comprehensive review explores the intricate relationship between NAFLD and neurodegenerative disorders, focusing on shared pathophysiological mechanisms, common risk factors, and emerging therapeutic strategies. Furthermore, it presents evidence of the association between NAFLD and neurodegenerative disorders from clinical studies, underscoring the importance of understanding and addressing these interconnected conditions. A broad understanding of the complex linking between NAFLD and neurodegenerative disorders is essential for the advancement of future therapeutic strategies that can effectively lessen the load of these devastating conditions. By unveiling the shared pathophysiological mechanisms, common risk factors, and interconnected pathways linking NAFLD and neurodegeneration, researchers can identify novel therapeutic targets and interventions aimed at halting disease progression and preserving patient health.