Branched-chain amino acids and their metabolites decrease human and rat hepatic stellate cell activation
BCAAs and their respective metabolites inhibit HSC activation with species-specific responses. Further research is needed to understand how BCAAs influence liver fibrogenesis. BCKAs supplementation could be a strategic approach for managing ESLDs, considering the nutritional status and amino acid profiles of patients.
Authors
- Hans Blokzijl (ORCID: https://orcid.org/0000-0003-4240-7506)
- Nils Bömer (ORCID: https://orcid.org/0000-0001-5926-6960)
- Karla Arevalo Gomez (ORCID: https://orcid.org/0000-0002-7317-8980)
- Han Moshage (ORCID: https://orcid.org/0000-0002-4764-0246)
- Vincent Erwin de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Frederike G.I. van Vilsteren (ORCID: https://orcid.org/0000-0002-8598-1017)
- María Camila Trillos-Almanza (ORCID: https://orcid.org/0000-0002-9714-5809)
- Magnolia Martinez Aguilar
- Manon Buist‐Homan (ORCID: https://orcid.org/0000-0002-8171-0797)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1007/s11033-024-10027-4
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Consejo Nacional de Ciencia y Tecnología