Culture Expansion Alters Human Bone Marrow–Derived Mesenchymal Stem Cell Production of Osteoarthritis‐Relevant Cytokines and Growth Factors
This study characterizes the in-vitro changes in BM-MSC secretome during culture expansion based on the cell source and culture medium. It suggests nonequivalence of culture-expanded BM-MSC therapies obtained from different donors using different culture media, even if delivering equivalent numbers of BM-MSCs.
Authors
- Andrew J. Moyal (ORCID: https://orcid.org/0009-0001-4826-5783)
- Tracey L. Bonfield (ORCID: https://orcid.org/0000-0001-9698-9113)
- James Everett Voos (ORCID: https://orcid.org/0000-0001-5693-0336)
- Ryan J. Furdock (ORCID: https://orcid.org/0000-0002-6865-9173)
- Jacob G. Calcei (ORCID: https://orcid.org/0000-0002-4895-1046)
- Arnold I. Caplan (ORCID: https://orcid.org/0000-0002-8677-6621)
Institutions
- Notre Dame College (US)
- University Hospitals of Cleveland (US)
- Center for Neuroscience and Regenerative Medicine (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Arthroscopy The Journal of Arthroscopic and Related Surgery
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1016/j.arthro.2024.10.034
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.44