Trichosanthin elicits antitumor activity via MICU3 mediated mitochondria calcium influx
Trichosanthin elicits antitumor activity in lung adenocarcinoma via repressing DNMT3B and increasing FOSL2, which in turn induces MICU3-mediated mitochondrial calcium influx and tumor cell death.
Authors
- Hongzhuan Chen (ORCID: https://orcid.org/0000-0002-5367-2949)
- Cong Zeng (ORCID: https://orcid.org/0000-0003-4423-3634)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-9040-3289)
- Yunbin Zhang (ORCID: https://orcid.org/0000-0002-2488-9970)
- Liming Lu (ORCID: https://orcid.org/0000-0002-2544-966X)
- Xuping Ding
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Institute of Immunology (HR)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1016/j.jare.2024.11.001
- Citations
- 6
- Primary Topic
- Photosynthetic Processes and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China