Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult‐Onset Still's Disease
Our study shows considerable genetic complexity within AOSD and demonstrates the potential utility of the ASC/NLRP3 specks assay for disease stratification and targeted treatment. The enriched genetic variants identified may not by themselves be sufficient to cause disease, but may contribute to a polygenic model for AOSD.
Authors
- Kenneth G. C. Smith (ORCID: https://orcid.org/0000-0003-3829-4326)
- Sinisa Savic (ORCID: https://orcid.org/0000-0001-7910-0554)
- Jan Zernicke (ORCID: https://orcid.org/0000-0002-5163-2177)
- Leon Chang (ORCID: https://orcid.org/0009-0003-5223-7616)
- Christopher M. Watson (ORCID: https://orcid.org/0000-0003-2371-1844)
- Bruno Fautrel (ORCID: https://orcid.org/0000-0001-8845-4274)
- Michael F. McDermott (ORCID: https://orcid.org/0000-0003-4417-4259)
- Eugen Feist (ORCID: https://orcid.org/0000-0002-9872-5282)
- Linda Pieper-Pournara (ORCID: https://orcid.org/0000-0002-3810-5524)
- Paul Lyons (ORCID: https://orcid.org/0000-0001-7035-8997)
- Jürgen Rech (ORCID: https://orcid.org/0000-0002-2569-2029)
- Samuel Lara‐Reyna (ORCID: https://orcid.org/0000-0002-9986-5279)
- Francesco Del Galdo (ORCID: https://orcid.org/0000-0002-8528-2283)
- Catherine Cargo (ORCID: https://orcid.org/0000-0002-5185-0190)
- Fatima Nadat (ORCID: https://orcid.org/0000-0002-6232-9173)
- James A. Poulter (ORCID: https://orcid.org/0000-0003-2048-5693)
- Clive Carter
- Alice Ibbotson
- Rebecca L. Ross (ORCID: https://orcid.org/0000-0001-7750-4280)
- Joanne Topping
Institutions
- University of Leeds (GB)
- Inserm (FR)
- The University of Melbourne (AU)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Walter and Eliza Hall Institute of Medical Research (AU)
- University of Cambridge (GB)
- Chapel Allerton Hospital (GB)
- St James's University Hospital (GB)
- National Institute for Health and Care Research (GB)
- Sorbonne Université (FR)
- Universitätsklinikum Erlangen (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- Pitié-Salpêtrière Hospital (FR)
- Charité - Universitätsmedizin Berlin (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1002/art.43054
- Citations
- 4
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Kennedy Trust for Rheumatology Research
- Horizon 2020 Framework Programme