Nanotechnology Based Alternative For The Topical Delivery Of Psoriasis

Psoriasis, a chronic autoimmune disease, is characterized by patches of abnormal skin that are red, pink, or purple, dry, itchy, and scaly. It affects people of all ages, with peak onset between 32 and 52 years old. Psoriasis is classified into three main types: vulgaris, pustular, and inverse. Novel Drug Delivery Systems (NDDS) offer innovative approaches to deliver pharmaceutical substances to the body more effectively and safely. These systems aim to increase bioavailability, maintain therapeutic drug concentrations, and minimize toxicity. Several NDDS are being used for psoriasis treatment, including: • Topical nanoparticles: These offer enhanced skin penetration, controlled release, and reduced side effects. • Liposomes: Spherical vesicles that can encapsulate drugs and deliver them to targeted areas. • Microneedle systems: Create microchannels in the skin for improved drug penetration and localized delivery. • Transdermal patches: Provide non-invasive, sustained drug delivery. • Smart drug delivery systems: Respond to specific stimuli, enabling targeted and controlled drug release