Pd-Catalyzed B–H Aryl/Alkenylation of 1,2-Azaborines
Direct functionalization of 1,2-azaborines to construct B–C bonds remains challenging. Here, we report a Pd-catalyzed B–H aryl/alkenylation reaction of 1,2-azaborines. The method provides a general platform to access diverse boron-substituted 1,2-azaborine compounds (>60 examples). The synthetic utility is highlighted through the late-stage modification of bioactive molecules, as well as the preparation and transformations of the 10B-enriched 1,2-azaborine product and the synthesis of four BN isostere analogues of bioactive molecules. And the reaction mechanism is also explored and discussed.
Authors
- P. P. Su (ORCID: https://orcid.org/0009-0006-8115-5603)
- Peiyuan Yu (ORCID: https://orcid.org/0000-0002-4367-6866)
- Kai Huai Yang (ORCID: https://orcid.org/0000-0002-1495-5380)
- Qiuling Song (ORCID: https://orcid.org/0000-0002-9836-8860)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-6512-8561)
- Dandan Jiang
Institutions
- Southern University of Science and Technology (CN)
- Henan Normal University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1021/acscatal.4c04576
- Citations
- 4
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- National Key Research and Development Program of China
- Science and Technology Planning Project of Shenzhen Municipality