Biochemical Screening, In-vitro and In-silico Characterization of Citrullus colocynthis Fruit Extracts: A Combined Experimental and Computation Study
The % cell viability of ethanolic (ET-PL), and aq. ethanolic extract of whole fruit and pulp showed promising results. The cancerous cell line U-87 seems to be more sensitive towards polar solvents (ethanolic and aq. ethanolic) pulp extracts than peel. Further, based on in-vitro results, compounds identified in ET-PP were screened for their potential as antibacterial and anticancer agents through molecular docking and MMGBSA studies. These studies strongly supported the in-vitro study results and identified new drug candidates.
Authors
- Farhan Younas (ORCID: https://orcid.org/0000-0001-6422-3842)
- Aneela Javed (ORCID: https://orcid.org/0000-0003-0280-0610)
- Nusrat Shafiq (ORCID: https://orcid.org/0000-0002-3270-4227)
- Syeda Aaliya Shehzadi (ORCID: https://orcid.org/0000-0002-6156-7006)
- Fatima Rida (ORCID: https://orcid.org/0009-0007-9200-7718)
- Muhammad Ashraf (ORCID: https://orcid.org/0000-0001-8152-5746)
- Waqar-Un-Nisa
- Waleed Younus
Institutions
- International Islamic University, Islamabad (PK)
- Hamdard University (PK)
- Government College Women University Faisalabad (PK)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.2174/0113892010332012241027022502
- Citations
- 1
- Primary Topic
- Advances in Cucurbitaceae Research
- Type
- article
- Field-Weighted Citation Impact
- 0.55