The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats
Our results demonstrate that treatment with atorvastatin can be used not only for its lipid-lowering properties and antioxidant effects but also to reduce Hcy concentration in this experimental model of diabetic rats. Moreover, atorvastatin therapy improves lipid profiles, reduces inflammation, suppresses oxidation, and decreases Hcy levels, potentially preventing major adverse cardiovascular events.
Authors
- Irene Paula Popa
- Dragoş Viorel Scripcariu (ORCID: https://orcid.org/0000-0002-9945-6328)
- Ionuţ Flaviu Faur (ORCID: https://orcid.org/0000-0001-6451-7461)
- Andreea Clim
- Roxana Nemțeanu (ORCID: https://orcid.org/0000-0001-5905-4546)
- Alin Constantin Pînzariu (ORCID: https://orcid.org/0000-0001-5730-1662)
- Nina Filip (ORCID: https://orcid.org/0000-0003-0949-7538)
- Mariana Floria (ORCID: https://orcid.org/0000-0002-9465-1503)
- Cristian Tudor Cozma (ORCID: https://orcid.org/0000-0001-7825-7832)
- Daniela Maria Tănase (ORCID: https://orcid.org/0000-0002-7144-2506)
- Ionela Lăcrămioara Șerban
- Minela Aida Maranducă (ORCID: https://orcid.org/0000-0002-2736-9700)
- Dragomir Nicolae Șerban (ORCID: https://orcid.org/0000-0001-6642-105X)
Institutions
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Institutul Regional de Oncologie (RO)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- Vasile Goldis Western University of Arad (RO)
- Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi (RO)
Publication Details
- Journal
- Life
- Published
- 2024-11-02
- DOI
- https://doi.org/10.3390/life14111414
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47