Super‐Enhancer–Driven Syndecan‐4 Regulates Intercellular Communication in Hypoxic Pulmonary Hypertension
Taken together, our results demonstrate that an SE-driven syndecan-4 modulates crosstalk of PASMCs and pulmonary artery endothelial cells and promotes vascular remodeling via the protein kinase C α and exosome pathway, thus providing potential targets for the early diagnosis and treatment of hypoxic PH.
Authors
- Yunwei Chen (ORCID: https://orcid.org/0000-0002-5144-925X)
- Cui Ma (ORCID: https://orcid.org/0000-0001-8413-5284)
- Xiangrui Zhu
- Xiaoying Wang
- Wei Huang (ORCID: https://orcid.org/0000-0002-8964-3955)
- Lixin Zhang (ORCID: https://orcid.org/0000-0002-6177-4152)
- Jian Mei
- Langlin Ou
- Zhaosi Wang
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1161/jaha.124.036757
- Citations
- 4
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68