Sestrin2 Attenuates Myocardial Endoplasmic Reticulum Stress and Cardiac Dysfunction During Ischemia/Reperfusion Injury
Sesn2 attenuates cardiac ER stress post-I/R injury via regulation of mTOR signaling. Thus, modulation of the mTOR pathway by Sesn2 could be a critical factor for maintaining cardiac ER homeostasis control during myocardial I/R injury.
Authors
- John E. Hall (ORCID: https://orcid.org/0000-0001-9867-5855)
- Jussara M. do Carmo (ORCID: https://orcid.org/0000-0003-0471-0512)
- Alan J. Mouton (ORCID: https://orcid.org/0000-0001-5973-3071)
- Ana Carolina Mieko Omoto (ORCID: https://orcid.org/0000-0003-1062-7109)
- Ji Li (ORCID: https://orcid.org/0000-0002-0899-4412)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-6377-3890)
- Xuan Li (ORCID: https://orcid.org/0000-0001-5781-1662)
- Alexandre A. da Silva (ORCID: https://orcid.org/0000-0003-4504-0607)
Institutions
- University of Mississippi Medical Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1161/jaha.124.035193
- Citations
- 8
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases