Biological evaluation of ZrO <sub>2</sub> composites modified with different ceramics additives

In this work, zirconia (ZrO<sub>2</sub>) composites modified with bioactive hydroxyapatite (HAp), hexagonal boron nitride (hBN), bioglass (BG), and bioglass with copper (BGCu) <i>via</i> the hydrothermal method were synthesized. The aim was to obtain highly bioactive and cytocompatible materials that could combine beneficial properties of inert and bioactive ceramics. Such materials could be applied as fillers for tooth extraction cavities, guaranteeing osseintegration without the need to introduce additional bone cements or other adhesives. It was proven that while all materials were favourable towards cells adhesion and growth, the HAp and BG-doped ones facilitated early adhesion, especially when compared to unmodified ZrO<sub>2</sub>. Only the HAp-doped materials showed satisfactory bioactivity results, with a well-developed apatite layer forming on their surfaces. This study confirms that the Hap-doped ZrO<sub>2</sub> is suitable for treating bone defects.

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Publication Details

Journal
Artificial Cells Nanomedicine and Biotechnology
Published
2024-11-04
DOI
https://doi.org/10.1080/21691401.2024.2422870
Citations
2
Primary Topic
Bone Tissue Engineering Materials
Type
article
Field-Weighted Citation Impact
0.37

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article

Biological evaluation of ZrO 2 composites modified with different ceramics additives

Elżbieta Menaszek, Magdalena Ziąbka, Barbara Zagrajczuk, Sebastian Komarek et al.
2 citations
Artificial Cells Nanomedicine and Biotechnology
Bone Tissue Engineering Materials
0.37
article

Biological evaluation of ZrO 2 composites modified with different ceramics additives

Elżbieta Menaszek, Magdalena Ziąbka, Barbara Zagrajczuk, Sebastian Komarek, Agnieszka Wojteczko, Aleksandra Benko
article en
2 citations

Abstract

In this work, zirconia (ZrO<sub>2</sub>) composites modified with bioactive hydroxyapatite (HAp), hexagonal boron nitride (hBN), bioglass (BG), and bioglass with copper (BGCu) <i>via</i> the hydrothermal method were synthesized. The aim was to obtain highly bioactive and cytocompatible materials that could combine beneficial properties of inert and bioactive ceramics. Such materials could be applied as fillers for tooth extraction cavities, guaranteeing osseintegration without the need to introduce additional bone cements or other adhesives. It was proven that while all materials were favourable towards cells adhesion and growth, the HAp and BG-doped ones facilitated early adhesion, especially when compared to unmodified ZrO<sub>2</sub>. Only the HAp-doped materials showed satisfactory bioactivity results, with a well-developed apatite layer forming on their surfaces. This study confirms that the Hap-doped ZrO<sub>2</sub> is suitable for treating bone defects.

Artificial Cells Nanomedicine and BiotechnologyVol. 52(1)
Jagiellonian University (PL), AGH University of Krakow (PL)
Akademia Górniczo-Hutnicza im. Stanislawa Staszica
Openalex Percentile: Top 42%
Bone Tissue Engineering Materials
0.37
DOIOpen Access PDFOpenAlex
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Biological evaluation of ZrO <sub>2</sub> composites modified with different ceramics additives — Elżbieta Menaszek, Magdalena Ziąbka, et al. · Artificial Cells Nanomedicine and Biotechnology (2024) | TGRS Research Map | TGRS