Mechanochemical difluoromethylations of ketones
We present a mechanochemical synthesis of difluoromethyl enol ethers. Utilizing an in situ generation of difluorocarbenes, ketones are efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.
Authors
- Carsten Bolm (ORCID: https://orcid.org/0000-0001-9415-9917)
- Pit van Bonn (ORCID: https://orcid.org/0000-0003-2900-1552)
Institutions
- RWTH Aachen University (DE)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3762/bjoc.20.235
- Citations
- 4
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- RWTH Aachen University