α‐Nucleophilic Addition to α,β‐Unsaturated Carbonyl Compounds via Photocatalytically Generated α‐Carbonyl Carbocations
We report the photocatalytic oxidation of α-carbonyl radicals of amides or esters to the corresponding α-carbonyl carbocations through super photoreductant CBZ6 induced redox-neutral photocatalysis. The α-carbonyl radicals are formed by the β-addition of alkyl radicals generated in situ by the photocatalytic fragmentation of N-hydroxyphthalimide esters to the α,β-unsaturated amides and esters. This method enables the α-nucleophilic addition of hydroxyl or alkoxyl radicals to amides and esters without any prefunctionalization.
Authors
- J.F. Chen
- Zhen‐Zhen Liu
- Yan‐Biao Kang (ORCID: https://orcid.org/0000-0002-7537-4627)
- Chong‐Jin Zhang
- Jian‐Ping Qu (ORCID: https://orcid.org/0000-0002-5002-5594)
- Fang Wang (ORCID: https://orcid.org/0000-0002-4306-1247)
- Hao Zhang (ORCID: https://orcid.org/0000-0003-2249-3179)
- Yu Sun (ORCID: https://orcid.org/0000-0003-2870-2410)
- Jie Gong
Institutions
- University of Science and Technology of China (CN)
- Nanjing Tech University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1002/anie.202415496
- Citations
- 11
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China