The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene–Environment Interaction Study
This study highlights the significant impact of genetic variation interacting with prenatal tobacco exposure on ALL risk. Further research is needed to understand these interactions and their implications for ALL etiology. Expanding studies to other gene-environment interactions will aid in developing targeted prevention, diagnosis, and treatment strategies for pediatric oncology.
Authors
- Nicholas Mancuso (ORCID: https://orcid.org/0000-0002-9352-5927)
- W. James Gauderman (ORCID: https://orcid.org/0000-0002-6626-9091)
- Joseph Leo Wiemels (ORCID: https://orcid.org/0000-0003-4838-9951)
- Catherine Metayer (ORCID: https://orcid.org/0000-0003-3467-4145)
- Charlie Zhong (ORCID: https://orcid.org/0000-0001-6973-887X)
- Xiaomei Ma (ORCID: https://orcid.org/0000-0001-9472-8032)
- Xinran Wang (ORCID: https://orcid.org/0009-0000-1805-3280)
Institutions
- University of Southern California (US)
- American Cancer Society (US)
- Yale University (US)
- Yale New Haven Health System (US)
- Berkeley Public Health Division (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1158/1055-9965.epi-24-1037
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- U.S. Environmental Protection Agency
- California Department of Public Health
- Tobacco-Related Disease Research Program
- University of Southern California
- Division of Cancer Prevention, National Cancer Institute
- Environmental Protection Agency
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute
- NIH Office of the Director
- National Cancer Institute
- National Institute of Environmental Health Sciences
- Common Fund