Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization
This study shows, for the first time, that GAGs from patients with Sanfilippo syndrome can induce microglial secretion of EVs that deliver a specific molecular message to recipient naive neurons, while promoting the neuroinflammation, and depriving neurons of neurodevelopmental factors. This work provides a framework for further studies of biomarkers to evaluate efficiency of emerging therapies.
Authors
- Jérôme Ausseil (ORCID: https://orcid.org/0000-0002-3059-9777)
- Christophe Santiago (ORCID: https://orcid.org/0009-0007-4994-5127)
- Chloé Dias (ORCID: https://orcid.org/0000-0003-0461-0116)
- Guillaume Morla (ORCID: https://orcid.org/0009-0001-0119-7090)
- Stéphanie Trudel (ORCID: https://orcid.org/0000-0003-1202-415X)
- Nissrine Ballout (ORCID: https://orcid.org/0000-0001-8301-3170)
- Adeline Chaubet (ORCID: https://orcid.org/0009-0003-9326-0935)
- Ida Chiara Guerrera (ORCID: https://orcid.org/0000-0002-4832-6793)
- Katia Alileche (ORCID: https://orcid.org/0009-0002-4898-4021)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s10020-024-00953-1
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Institut National de la Santé et de la Recherche Médicale