Unearthing a Prostate Cancer cfDNA Signature that “Stems” from AR Alterations
Androgen receptor alterations portend a poor prognosis in patients with advanced prostate cancer. A recent study identified a stemness signature enriched in cell-free DNA from androgen receptor-altered patients, associated with worse outcomes. These findings highlight the potential of epigenomic liquid biopsy tools to discover novel clinically relevant tumor molecular subtypes. See related article by Chauhan et al., p. 151.
Authors
- Rashad Nawfal (ORCID: https://orcid.org/0000-0001-5428-5660)
- Razane El Hajj Chehade (ORCID: https://orcid.org/0009-0007-3424-6585)
- Jacob E. Berchuck (ORCID: https://orcid.org/0000-0002-7607-2428)
Institutions
- Emory University (US)
- Piedmont Cancer Institute (US)
- Dana-Farber Cancer Institute (US)
- Winship Cancer Institute
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2849
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- DOD Prostate Cancer Research Program