Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours
This study is the first to investigate GRPR expression in a large cohort of GIST tumours. Our results demonstrate that most GIST tumours exhibit a moderate to high expression of the receptor, suggesting that GRPR theranostics could be a viable option for TKI-resistant GIST. Interestingly, tumours that were pretreated with TKI showed lower expression levels of GRPR, indicating a need for further studies to explore this finding.
Authors
- Anders Thornell (ORCID: https://orcid.org/0000-0003-4779-5042)
- Marta Berndsen (ORCID: https://orcid.org/0000-0002-7357-6161)
- Yvonne Arvidsson (ORCID: https://orcid.org/0000-0002-9599-3791)
- S. Lindskog (ORCID: https://orcid.org/0000-0001-8055-5003)
- Florian Puls (ORCID: https://orcid.org/0000-0002-9841-4230)
- Andreas Muth (ORCID: https://orcid.org/0000-0003-0857-1521)
- Erik Elias (ORCID: https://orcid.org/0000-0002-1624-3432)
Institutions
- Varberg Hospital (SE)
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- ESMO Gastrointestinal Oncology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1016/j.esmogo.2024.100105
- Citations
- 4
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.86