Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation
This is the first study to reveal the non-pyroptotic role of GSDME in macrophage polarization, revealing that metformin could be used in combination with cisplatin to reduce intestinal toxicity.
Authors
- Jiangbo Li (ORCID: https://orcid.org/0000-0001-7856-9131)
- Yuanyuan Jiao (ORCID: https://orcid.org/0009-0000-7192-2676)
- Ligai Bai (ORCID: https://orcid.org/0000-0002-7636-2716)
- Zhenqiao Wei
- Ke Jiang (ORCID: https://orcid.org/0000-0001-7959-7716)
- Yuke Cui (ORCID: https://orcid.org/0000-0003-0150-3438)
- Jingqi Shi
- Changdong Zhou
- Shengqi Wang (ORCID: https://orcid.org/0000-0001-8100-7295)
- Liang Guo (ORCID: https://orcid.org/0000-0001-7353-8336)
- Qi He (ORCID: https://orcid.org/0000-0002-2856-6626)
- Wen Yang (ORCID: https://orcid.org/0000-0003-3281-7544)
- Jian Li (ORCID: https://orcid.org/0000-0001-6779-1167)
- Chenhui Wang
Institutions
- Hebei University (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3390/biomedicines12112526
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23