C4b-Binding Protein and Factor H Attenuate NLRP3 Inflammasome-Mediated Signalling Response during Group A Streptococci Infection in Human Cells
Given that the amount of IL-1β modulates the severity of GAS infection, our results provide new insights into the effect of FH and internalised C4BP to control GAS sensing by inflammasomes.
Authors
- Michal Magda (ORCID: https://orcid.org/0000-0003-4857-0769)
- Maisem Laabei (ORCID: https://orcid.org/0000-0002-8425-3704)
- Ben C. King (ORCID: https://orcid.org/0000-0001-6776-8741)
- Kristian Riesbeck (ORCID: https://orcid.org/0000-0001-6274-6965)
- Maja Chrobak
- Mateusz Dziedzic (ORCID: https://orcid.org/0000-0002-0601-074X)
- Damiën Bierschenk (ORCID: https://orcid.org/0000-0003-1647-8837)
- Serena Bettoni (ORCID: https://orcid.org/0000-0002-7840-4596)
- Anna Marie Blom (ORCID: https://orcid.org/0000-0002-1348-1734)
Institutions
- Lund University (SE)
- University of Bristol (GB)
- University of Bath (GB)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1159/000542434
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Skåne County Council's Research and Development Foundation
- UK Research and Innovation
- University of Bristol
- Vetenskapsrådet
- Universiteit Gent
- Stiftelsen Lars Hiertas Minne
- Engineering and Physical Sciences Research Council