Comparing the performance of DeoxyriboNucleic Acid methylation analysis and cytology for detecting cervical (pre)cancer in women with high-risk human papillomavirus-positive status in a gynecologic outpatient population
PAX1<sup>m</sup> and GYPC<sup>m</sup> demonstrated superior ability to identify cervical precancerous lesions and cervical cancer, with AUC values exceeding 0.85. For detecting CIN2+/CIN3+ in women with hrHPV-positive status, DNA methylation (combined with HPV 16/18) showed higher specificity than cytology (combined with HPV 16/18) and is a potential molecular biomarker for detecting cervical (pre)cancer.
Authors
- Yu Fang (ORCID: https://orcid.org/0000-0001-6911-4047)
- Saiping Mao
- Hong Tao (ORCID: https://orcid.org/0000-0003-0019-3861)
- Xing Fan (ORCID: https://orcid.org/0009-0004-5639-0463)
- Xiaojian Pei
- Yang Li (ORCID: https://orcid.org/0000-0002-0112-1328)
Institutions
- Hunan Normal University (CN)
- Changsha Hospital for Maternal and Child Health Care (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12885-024-13126-4
- Citations
- 5
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.93