Effects of atmospheric pressure change during flight on insulin pump delivery and glycaemic control of pilots with insulin-treated diabetes: an in vitro simulation and a retrospective observational real-world study
Ambient pressure reduction during simulated flights results in bubble formation and expansion within insulin cartridges. This causes unintended delivery of small insulin doses independent of pre-determined delivery rates and represents the maximum amount of insulin that could be delivered and retracted. However, in vivo, pilots using CSII in-flight did not experience a fall in blood glucose or episodes of hypoglycaemia during these atmospheric pressure changes and the use of insulin pumps can be endorsed in view of their clinical benefits.
Authors
- Brian M. Frier (ORCID: https://orcid.org/0000-0002-9590-9473)
- Monika Cigler (ORCID: https://orcid.org/0000-0001-5827-7991)
- Ka Siu Fan (ORCID: https://orcid.org/0000-0002-0861-1944)
- Thomas Rudolf Pieber (ORCID: https://orcid.org/0000-0003-3554-0405)
- Kenneth M. Shaw (ORCID: https://orcid.org/0000-0002-0846-3013)
- Julia Katharina Mader (ORCID: https://orcid.org/0000-0001-7854-4233)
- Declan Maher
- Ewan J. Hutchison
- Felice Strollo (ORCID: https://orcid.org/0000-0001-8917-5314)
- Victoria Edwards (ORCID: https://orcid.org/0000-0002-3314-0013)
- Richard Helsdingen
- Gerd Koehler
- Simon Heller (ORCID: https://orcid.org/0000-0002-2425-9565)
- Chantal Mathieu (ORCID: https://orcid.org/0000-0002-4055-5233)
- Stuart Mitchell (ORCID: https://orcid.org/0009-0006-3757-0893)
- Monique Borg Inguanez (ORCID: https://orcid.org/0000-0003-3496-7132)
- Bruce R. King (ORCID: https://orcid.org/0000-0002-8958-7404)
- Vivienne Lee
- Graham Roberts (ORCID: https://orcid.org/0000-0002-5018-0391)
- Elisabeth M. W. Eekhoff (ORCID: https://orcid.org/0000-0001-5399-676X)
- Renald Meçani (ORCID: https://orcid.org/0000-0003-2697-8544)
- David Russell‐Jones (ORCID: https://orcid.org/0000-0002-9490-2480)
- Fariba Shojaee‐Moradie (ORCID: https://orcid.org/0000-0002-3514-0447)
- Gillian L. Garden (ORCID: https://orcid.org/0000-0003-1111-8541)
- M. Lindsay Paterson (ORCID: https://orcid.org/0009-0005-1091-1603)
- Gerd Köhler
- Antonios Manoli
Institutions
- Qinetiq (United Kingdom) (GB)
- University of Malta (MT)
- Medical University of Graz (AT)
- Civil Aviation Authority (GB)
- University College Cork (IE)
- University of Surrey (GB)
- Austro Control (Austria) (AT)
- Swansea University (GB)
- Hunter Medical Research Institute (AU)
- Mercy University Hospital (IE)
- John Hunter Children's Hospital (AU)
- Royal Surrey NHS Foundation Trust (GB)
- The Queen's Medical Research Institute (GB)
- University of Portsmouth (GB)
- University of Newcastle Australia (AU)
- University of Sheffield (GB)
- University of Edinburgh (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1007/s00125-024-06295-1
- Citations
- 10
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- Insulet Corporation
- Tandem Diabetes Care
- European Association for the Study of Diabetes