Compound 7 regulates microglia polarization and attenuates radiation-induced myelopathy via the Nrf2 signaling pathway in vivo and in vitro studies
C7 could ameliorate RM by boosting Nrf2 signaling and promoting M2 phenotype microglia polarization in vitro and in vivo.
Authors
- Shuang Yang (ORCID: https://orcid.org/0000-0001-7958-0594)
- Yanze Sun (ORCID: https://orcid.org/0000-0001-6738-3841)
- Z Qian
- Zhiqiang Zhou (ORCID: https://orcid.org/0000-0002-5144-095X)
- Han Wu (ORCID: https://orcid.org/0000-0003-4349-3792)
- Shengwen Calvin Li (ORCID: https://orcid.org/0000-0002-9699-9204)
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Hongxia Cui (ORCID: https://orcid.org/0000-0002-7482-6206)
- Jianzhuo Jiang
- Peng Zhang (ORCID: https://orcid.org/0000-0001-8344-101X)
Institutions
- Jiangsu University (CN)
- Soochow University (CN)
- First People's Hospital of Kunshan (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Yixing People's Hospital (CN)
- Jingning County People's Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s10020-024-00951-3
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Science and Technology Program of Zhejiang Province