Whole-body MRI-based long-term evaluation of pediatric NF1 patients without initial tumor burden with evidence of newly developed peripheral nerve sheath tumors
Our results indicate that PN can be newly detected in pediatric patients over time, even if no PN were detected on initial MRI scans. Therefore, it seems reasonable to perform at least a second MRI in pediatric NF1 patients at transition to adulthood, even if they did not display any tumor burden on initial MRI, and when the MRI was performed significantly under the age of 18. With this approach, tumors that may have developed between scans can be detected and patients at risk for complications can be identified.
Authors
- Lan Kluwe (ORCID: https://orcid.org/0000-0001-9919-4551)
- Lennart Well (ORCID: https://orcid.org/0000-0003-2491-1346)
- Said Farschtschi (ORCID: https://orcid.org/0000-0002-3596-5932)
- Marie‐Lena Schmalhofer (ORCID: https://orcid.org/0000-0003-4991-8544)
- Gerhard Adam (ORCID: https://orcid.org/0000-0001-7976-3868)
- Inka Ristow (ORCID: https://orcid.org/0000-0002-3032-2321)
- Victor F. Mautner
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s13023-024-03420-6
- Citations
- 4
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Deutsche Forschungsgemeinschaft